3-甲基-3-丁烯-1-醇合成路线 （共 220 条）
反应条件
[Ru(PnOct3)4(H)2] T=120°C; 20 h; RefluxInert atmosphereSchlenk technique;
参考文献
EP2597081 A1, ;
Paragraph 0124 ;
反应条件
sulfuric acid; hydrogen bromide; acetic acid das Acetat entsteht;
参考文献
Laforgue
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1948 , vol. 227, p. 353
反应条件
1: 92 percent / Amberlyst H15 / light petroleum / 47 h / Ambient temperature 2: 1.) borane-1,4-oxathiane, 2.) 3M NaOH, 9.8M H2O2 / 1.) light petroleum, r.t., 2 h, 2.) light petroleum, ethanol, water, reflux, 1.5 h View Scheme
参考文献
Ladlow, Mark; Pattenden, Gerald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1107 - 1118
反应条件
hydrogen in ethanol T=20°C; P=760.051 Torr; 1 h; chemoselective reaction;
参考文献
Kantam, Mannepalli Lakshmi; Kishore, Ramineni; Yadav, Jagjit; Sudhakar, Medak; Venugopal, Akula
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 663 - 669
反应条件
[Ru(COD)(Cl2)]2; potassium tert-butylate; 1-n-butyl-3-methylimidazolium chloride; tri-cyclo-hexyl-phosphine in toluene 12 h; RefluxInert atmosphereSchlenk technique;
参考文献
EP2597081 A1, ;
Paragraph 0124 ;
参考文献
BASF Aktiengesellschaft
Patent: US4310709 A1, 1982 ;
反应条件
1: [Ru(COD)(Cl2)]2; 1-n-butyl-3-methylimidazolium chloride; potassium tert-butylate; tri-cyclo-hexyl-phosphine / toluene / 12 h / |Reflux; |Inert atmosphere; |Schlenk technique 2: [Ru(COD)(Cl2)]2; 1-n-butyl-3-methylimidazolium chloride; potassium tert-butylate; tri-cyclo-hexyl-phosphine / toluene / 12 h / |Reflux; |Inert atmosphere; |Schlenk technique View Scheme
参考文献
BASF SE; SCHAUB, Thomas; BRUNNER, Bernhard; EBEL, Klaus; PACIELLO, Rocco
Patent: WO2013/76226 A1, 2013 ;
反应条件
1: [Ru(COD)(Cl2)]2; 1-n-butyl-3-methylimidazolium chloride; potassium tert-butylate; tri-cyclo-hexyl-phosphine / toluene / 12 h / |Reflux; |Inert atmosphere; |Schlenk technique 2: dcype; [Ru(Pn-Bu3)4H2] / toluene / 12 h / |Reflux; |Inert atmosphere; |Schlenk technique View Scheme
反应条件
nitric acid; sodium nitrite 1) 20 deg C, 4 h, 2) 50-60 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Sargsyan, M. S.; Mkrtumyan, S. A.; Avakyan, O. V.; Manukyan, A. T.; Gevorkyan, A. A.
Chemistry of Natural Compounds, 1991 , vol. 27, # 3 p. 270 - 271
Khimiya Prirodnykh Soedinenii, 1990 , # 3 p. 313 - 314
反应条件
1: 1.)n-BuLi, TMEDA, 2.) 5percent HCl / 1.) hexane, HMPA, -23 deg C, 30 min; room temperature, 8 h 2: 91 percent / Et3N / diethyl ether / 2 h / Ambient temperature 3: 70 percent / KOH, 18-crown-6 / toluene / 1 h / 80 °C View Scheme
参考文献
Synthetic Communications, , vol. 17, # 2 p. 173 - 180
