甲基亚磺酰甲基2-乙酰基氧基苯甲酸酯合成路线 (共 3 条)
反应条件
10 percent human plasma in acetonitrile T=37°C; phosphate buffer (pH 7.4); or in undiluted plasma; Rate constant;
参考文献
Nielsen; Bundgaard
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 727 - 734
反应条件
Carbonate buffer in acetonitrile T=50.8°C; hydrolysis, pH dependence, various aspirin prodrugs; Rate constantMechanismProduct distribution;
参考文献
Loftsson; Bodor
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 750 - 755
反应条件
Carbonate buffer in acetonitrile T=50.8°C; hydrolysis, pH dependence, various aspirin prodrugs; Rate constantMechanismProduct distribution;
参考文献
Loftsson; Bodor
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 7 p. 750 - 755