2-甲基-1,3-环戊二酮合成路线 （共 110 条）
反应条件
1: 68.5 percent / PBr3 / CHCl3 / 24 h / Heating 2: 76.5 percent / NaOH / ethanol / 14 h / Ambient temperature 3: lithium aluminum hydride / diethyl ether / 1) r.t., 30 min.; 2) reflux, 1.5 h 4: 5 percent HCl / acetone / 0.08 h / 40 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 1 p. 368 - 372
参考文献
Journal of Organic Chemistry, , vol. 69, # 26 p. 9299 - 9302
反应条件
1: 89 percent / Et3N / ethyl acetate / 12 h / 25 °C 2: 60 percent / D-CSA; L-Phe / acetonitrile / 120 h / 25 - 70 °C View Scheme
参考文献
Sakai, Hitoshi; Hagiwara, Hisahiro; Yoshiaki, Ito; Hoshi, Takashi; Suzuki, Toshio; Ando, Masayoshi
Tetrahedron Letters, 1999 , vol. 40, # 15 p. 2965 - 2968
反应条件
perchloric acid; 2-aminoisovaleric acid; toluene-4-sulfonic acid; acetic acid Multistep reaction. Title compound not separated from byproducts;
参考文献
Paquette, Leo A.; Wang, Ting-Zhong; Sivik, Matthew R.
Journal of the American Chemical Society, 1994 , vol. 116, # 25 p. 11323 - 11334
反应条件
2: H2 / Pd-CaCO3 View Scheme
参考文献
Douglas,G.H. et al.
Journal of the Chemical Society, 1963 , p. 5072 - 5094
反应条件
acetic acid; propionic acid in toluene 6 h; Heating;
参考文献
Otto; Schick
Synthesis, 1991 , # 2 p. 115 - 116
反应条件
tetra(n-butyl)ammonium hydroxide in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Suzuki, Takeyuki; Uozumi, Yasuhiro; Shibasaki, Masakatsu
Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1593 - 1595
反应条件
1: KOH / methanol / Heating 2: aq. HCl / methanol; ethyl acetate View Scheme
参考文献
Heidepriem,H. et al.
Justus Liebigs Annalen der Chemie, 1968 , vol. 712, p. 155 - 167
反应条件
potassium hydroxide in methanol Heating;
参考文献
Heidepriem,H. et al.
Justus Liebigs Annalen der Chemie, 1968 , vol. 712, p. 155 - 167
反应条件
1: 1.) sec-BuOH, H+ 2: 73 percent / diethyl ether / -78 deg C - r.t. View Scheme
参考文献
Tanaka; Sakai
Tetrahedron Letters, 1991 , vol. 32, # 40 p. 5581 - 5584
