1-苯基-2,2-二甲基环丙烷合成路线 （共 37 条）
反应条件
1: Zn(CH2I)2 With ethylene glycol dimethyl ether; trichloroacetic acid in hexane; dichloromethane
T=-15°C; Simmons-Smith Cyclopropanation; 1 h; Schlenk techniqueInert atmosphere;
2: 2-methyl-1-phenyl-1-propene in hexane; dichloromethane
T=-15 - 25°C; Simmons-Smith Cyclopropanation; 18 h; Schlenk techniqueInert atmosphere;
参考文献
Cheng, Donghao; Huang, Deshun; Shi, Yian
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 34 p. 5588 - 5591
反应条件
isopropylmagnesium chloride in tetrahydrofuran
T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Satoh, Tsuyoshi; Musashi, Jun; Kondo, Atsushi
Tetrahedron Letters, 2005 , vol. 46, # 4 p. 599 - 602
参考文献
Closs,G.L.; Moss,R.A.
Journal of the American Chemical Society, 1964 , vol. 86, p. 4042 - 4053
反应条件
bis(acetylacetonate)nickel(II); methyllithium in tetrahydrofuran; diethyl ether
T=65°C; 1 h;
参考文献
Gai, Yonghua; Julia, Marc; Verpeaux, Jean-Noel
Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 9 p. 817 - 829
反应条件
potassium tert-butylate in dimethyl sulfoxide
Cyclization; 6 h;
参考文献
Argueello, Juan E.; Penenory, Alicia B.; Rossi, Roberto A.
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 6115 - 6118
反应条件
sodium in ethylene glycol
参考文献
Kirmse,W. et al.
Chemische Berichte, 1966 , vol. 99, p. 2579 - 2592
反应条件
potassium tert-butylate in dimethyl sulfoxide
Cyclization; 0.5 h; Title compound not separated from byproducts;
参考文献
Argueello, Juan E.; Penenory, Alicia B.; Rossi, Roberto A.
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 6115 - 6118
反应条件
1: Bu3P / tetrahydrofuran
2: m-chlorobenzoic acid
3: NCS / CCl4
4: isopropylmagnesium chloride / tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Satoh, Tsuyoshi; Musashi, Jun; Kondo, Atsushi
Tetrahedron Letters, 2005 , vol. 46, # 4 p. 599 - 602
反应条件
1: m-chlorobenzoic acid
2: NCS / CCl4
3: isopropylmagnesium chloride / tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Satoh, Tsuyoshi; Musashi, Jun; Kondo, Atsushi
Tetrahedron Letters, 2005 , vol. 46, # 4 p. 599 - 602
反应条件
1: NCS / CCl4
2: isopropylmagnesium chloride / tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Satoh, Tsuyoshi; Musashi, Jun; Kondo, Atsushi
Tetrahedron Letters, 2005 , vol. 46, # 4 p. 599 - 602
