1-丙炔-2-吡咯烷-2-酮合成路线 （共 8 条）
反应条件
potassium tert-butylate in tetrahydrofuran T=20°C; Isomerization;
参考文献
Wei, Lin-Li; Mulder, Jason A.; Xiong, Hui; Zificsak, Craig A.; Douglas, Christopher J.; Hsung, Richard P.
Tetrahedron, 2001 , vol. 57, # 3 p. 459 - 466
反应条件
potassium hydroxide; tetrabutylammomium bromide in tetrahydrofuran
6 h; Ambient temperature;
参考文献
Nilsson, Bjoern M.; Ringdahl, Bjoern; Hacksell, Uli
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 580 - 584
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in tetrahydrofuran
4 h; Heating;
参考文献
Fenandez, Israel; Monterde, Maria I.; Plumet, Joaquin
Tetrahedron Letters, 2005 , vol. 46, # 36 p. 6029 - 6031
反应条件
potassium hydroxide; tetra-(n-butyl)ammonium iodide in tetrahydrofuran
参考文献
Disingrini, Teresa; Muth, Mathias; Dallanoce, Clelia; Barocelli, Elisabetta; Bertoni, Simona; Kellershohn, Kerstin; Mohr, Klaus; De Amici, Marco; Holzgrabe, Ulrike
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 366 - 372
反应条件
p-nitrobenzenesulfonyl peroxide
1.) -78 deg C, dichloromethane, 2.) 25 deg C; Yield given. Multistep reaction;
参考文献
Hoffman, Robert V.; Salvador, James M.
Tetrahedron Letters, 1989 , vol. 30, # 32 p. 4207 - 4210
反应条件
copper(l) chloride in 1,4-dioxane
T=70°C; 3 h;
参考文献
Moon; Chidester; Heier; Morris; Collins; Russell; Francis; Sage; Sethy
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2314 - 2327
反应条件
copper(l) chloride in 1,4-dioxane
T=70°C; 3 h;
参考文献
Disingrini, Teresa; Muth, Mathias; Dallanoce, Clelia; Barocelli, Elisabetta; Bertoni, Simona; Kellershohn, Kerstin; Mohr, Klaus; De Amici, Marco; Holzgrabe, Ulrike
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 366 - 372
参考文献
Resul; Lewander; Zetterstrom; et al.
Journal of Pharmacy and Pharmacology, 1980 , vol. 32, # 6 p. 439 - 440
