2,2,6,6-四甲基哌啶合成路线 （共 107 条）
反应条件
n-butyllithium in diethyl ether; hexane under inert atmosphere, piperidine in hexane reacted with n-BuLi in hexane, dropwise addn. of GaBr3 in diethyl ether at room temp., refluxed for 30 min, stirred at room temp. for 12 h; evapn. of solvent, taken up in pentane, filtered, evapd. in vac.; elem. anal.;
参考文献
Linti, Gerald; Frey, Ronald; Polborn, Kurt
Chemische Berichte, 1994 , vol. 127, # 8 p. 1387 - 1394
反应条件
methyllithium 1.) -78 deg C, ether, 2.) 5 h, room temp., ether; Multistep reaction;
参考文献
Creary, Xavier
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2419 - 2425
参考文献
Kostyanovskii, R. G.; Shakhgel'diev, M. A.; Nabiev, O. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 12 p. 2593
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 12 p. 2826 - 2827
参考文献
Ciba-Geigy Corporation
Patent: US4208525 A1, 1980 ;
反应条件
diethyl ether; ethanol; potassium carbonate
参考文献
Leonard; Hauck
Journal of the American Chemical Society, 1957 , vol. 79, p. 5279,5286
反应条件
ethylmagnesium bromide 1.) Et2O, reflux, 5 h, 2.) Et2O; Yield given. Multistep reaction;
参考文献
Kobayashi, Kazuhiro; Kawakita, Masataka; Yokota, Kouichi; Mannami, Tohru; Yamamoto, Koji; et al.
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 5 p. 1401 - 1408
反应条件
1: With n-butyllithium in diethyl ether; hexane T=-78°C; 0.166667 h; Inert atmosphere; 2: With 2,3-dichloropyridine in diethyl ether; hexane T=-78°C; 0.5 h; 3: With iodine in diethyl ether; hexane T=20°C;
参考文献
Janssen Pharmaceuticals, Inc.; Andrés-Gil, José Ignacio; Alcázar-Vaca, Manuel Jesús; Cid-Núñez, José Maria; Trabanco-Suárez, Andrés Avelino; Bormans, Guy Maurits R.; Celen, Sofie Jeanne Leopoldine; Koole, Michel
Patent: US2013/230459 A1, 2013 ;
Location in patent: Paragraph 0154 ;
反应条件
in tetrahydrofuran; diethyl ether T=27°C; Equilibrium constant;
参考文献
Fraser, Robert R.; Mansour, Tarek S.; Savard, Sylvain
Journal of Organic Chemistry, 1985 , vol. 50, # 17 p. 3232 - 3234
反应条件
n-butyllithium in tetrahydrofuran; N-methyl-acetamide; hexane
参考文献
EP950418 A2, ;
EP 0950418 A2
反应条件
hydrogen bromide in tetrahydrofuran 0.25 h; Ambient temperature;
参考文献
Hellrung, Bernhard; Doelling, Wolfgang
Journal fur Praktische Chemie - Chemiker - Zeitung, 1996 , vol. 338, # 2 p. 157 - 164
