2,2,6,6-四甲基哌啶合成路线 （共 107 条）
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; water
参考文献
Wood, Michael R.; Anthony, Neville J.; Bock, Mark G.; Feng, Dong-Mei; Kuduk, Scott D.; Su, Dai-Shi; Wai, Jenny Miu-chun
Patent: US2003/220375 A1, 2003 ;
反应条件
RuO4 in tetrachloromethane 3.5 h;
参考文献
Perrone; Carbonara; Tortorella
Archiv der Pharmazie, 1984 , vol. 317, # 7 p. 635 - 639
反应条件
in tetrahydrofuran T=-47°C; Equilibrium constant;
参考文献
Fraser, Robert R.; Baignee, Alison; Bresse, Monique; Hata, Kazumi
Tetrahedron Letters, 1982 , vol. 23, # 41 p. 4195 - 4198
反应条件
Xtalfluor-E® in tetrahydrofuran T=0 - 20°C; 4 h; Inert atmosphereCooling with ice;
参考文献
Orliac, Aurelie; Gomez Pardo, Domingo; Bombrun, Agnes; Cossy, Janine
Organic Letters, 2013 , vol. 15, # 4 p. 902 - 905
反应条件
sodium in chlorobenzene; toluene
参考文献
K%⦼& I Chemical Industry Co., Ltd.
Patent: US6024897 A1, 2000 ;
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; hexane; N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche Inc.
Patent: US5162577 A1, 1992 ;
反应条件
1: 2,2,6,6-tetramethyl-piperidine With n-butyllithium in tetrahydrofuran; hexane T=-10°C; 2: tri-isopropoxy-borane; benzonitrile in tetrahydrofuran; hexane T=-78°C; 2 h; 3: With water; ammonium chloride in tetrahydrofuran; hexane T=20°C;
参考文献
Nakamura, Shinichiro
Patent: US2009/184289 A1, 2009 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: 2,2,6,6-tetramethyl-piperidine With n-butyllithium in tetrahydrofuran; hexane T=-20°C; 2: tri-isopropoxy-borane; benzonitrile in tetrahydrofuran; hexane T=-80°C; 0.25 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=-40°C; Product distribution / selectivity;
参考文献
Nakamura, Shinichiro
Patent: US2009/184289 A1, 2009 ;
Location in patent: Page/Page column 4 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane; ethyl acetate
参考文献
Neurogen Corporation
Patent: US2003/220348 A1, 2003 ;
US 20030220348 A1
反应条件
in tetrahydrofuran; hexane
参考文献
Zeneca Limited
Patent: US6265411 B1, 2001 ;
