5-氨基-2,4,6-三碘-N,N’-二(2,3-二羟基丙基)-1,3-苯二甲酰胺合成路线 （共 10 条）
反应条件
KIO3; sulfuric acid; iodine; sodium sulfate in water T=65 - 80°C; 47 h;
参考文献
HOVIONE CHINA HOLDING LIMITED; HU, Zhiqi; XING, Hongdeng; LI, Lei
Patent: WO2013/63737 A1, 2013 ;
Location in patent: Page/Page column 20 ;
参考文献
Mallinckrodt, Inc.
Patent: US5013865 A1, 1991 ;
参考文献
Nyegaard and Co. A/S
Patent: US4250113 A1, 1981 ;
反应条件
1: 74 percent / aq. potassium iododichloride / H2O / 18 h / 55 - 60 °C 2: 92 percent / thionyl chloride 3: N,N-dimethyl-acetamide / 16 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 6 p. 1344 - 1350
反应条件
1: 92 percent / thionyl chloride 2: N,N-dimethyl-acetamide / 16 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 6 p. 1344 - 1350
反应条件
1: sodium methylate / methanol / 80 h 2: hydrogen / water / 10 h / 11251.1 Torr 3: iodine; KIO3; sodium sulfate; sulfuric acid / water / 47 h / 65 - 80 °C View Scheme
反应条件
in N,N-dimethyl acetamide 16 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 59, # 6 p. 1344 - 1350
反应条件
1: With toluene-4-sulfonic acid 2: With sodium hydroxide in methanol; water T=50 - 60°C; pH=12; 3: With hydrogenchloride in methanol; water T=60°C; pH=10.5 - 11.5;
参考文献
GE Healthcare AS
Patent: EP2281814 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
1: in acetic acid T=55 - 120°C; 2 h; 2: With methanol
参考文献
GE Healthcare AS
Patent: EP2277851 A1, 2011 ;
Location in patent: Page/Page column 4; 5 ;
参考文献
GE Healthcare AS
Patent: EP2281791 A1, 2011 ;
Location in patent: Page/Page column 5 ;
