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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
喜树碱
合成路线
（共 215 条）
1353579-43-7
→
反应条件
7689-03-4
喜树碱
反应条件
1.1: hydrogenchloride; water / methanol / 2 h / 20 °C 2.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 3.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 3.2: 2 h / 20 °C 4.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 5.1: hydrogenchloride; water / 3 h / 100 °C 6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 7.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 713 - 717
1353579-45-9
→
反应条件
7689-03-4
喜树碱
反应条件
1.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 2.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 2.2: 2 h / 20 °C 3.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 4.1: hydrogenchloride; water / 3 h / 100 °C 5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 6.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 713 - 717
1201830-88-7
→
反应条件
7689-03-4
喜树碱
反应条件
1.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 1.2: 2 h / 20 °C 2.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 3.1: hydrogenchloride; water / 3 h / 100 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 5.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 713 - 717
1201830-89-8
→
反应条件
7689-03-4
喜树碱
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 2: hydrogenchloride; water / 3 h / 100 °C 3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 4: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 713 - 717
158669-24-0
→
反应条件
7689-03-4
喜树碱
反应条件
1: hydrogenchloride; water / 3 h / 100 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 3: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 713 - 717
1334446-19-3
+
146683-25-2
(4S)-4-乙基-4-羟基-1H-吡喃并[3,4-c]吡啶-3,8(4h,7h)-二酮
→
反应条件
7689-03-4
喜树碱
反应条件
1.1: potassium tert-butylate / ethylene glycol dimethyl ether / 0.5 h / 20 °C 1.2: 12 h / Reflux 2.1: bis(acetato)bis(triphenylphosphine)palladium(0); potassium acetate / acetonitrile / 12 h / 100 °C / Inert atmosphere View Scheme
参考文献
Synthesis, , # 24 art. no. F87011SS, p. 4045 - 4049
35740-83-1
+
146683-25-2
(4S)-4-乙基-4-羟基-1H-吡喃并[3,4-c]吡啶-3,8(4h,7h)-二酮
→
反应条件
7689-03-4
喜树碱
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 713 - 717
64-19-7
醋酸
+
53544-22-2
→
反应条件
19685-09-7
+
19685-11-1
+
7689-03-4
喜树碱
反应条件
lead(IV) acetate 0.25 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 12 p. 3183 - 3188
53544-22-2
→
反应条件
19685-09-7
+
7689-03-4
喜树碱
反应条件
lead(IV) acetate; trifluoroacetic acid 0.25 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 12 p. 3183 - 3188
34079-22-6
→
反应条件
7689-03-4
喜树碱
反应条件
Britton-Robinson's buffer pH 6.0; water T=37°C; Ea, A, var. pH, var. temp., var. time; Equilibrium constantKineticsThermodynamic data;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 10 p. 2135 - 2138
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