1,3-二甲基巴比妥酸合成路线 （共 143 条）
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; L-proline in dimethyl sulfoxide
T=25°C; 24 h;
参考文献
Ramachary, Dhevalapally B.; Kishor, Mamillapalli; Reddy, Y. Vijayendar
European Journal of Organic Chemistry, 2008 , # 6 p. 975 - 993
反应条件
1: trichlorophosphate / water / 3 h / Reflux
2: nitric acid / sulfuric acid / 2 h / 10 °C
3: dichloromethane; chloroform; water / 1 h / 20 °C / Inert atmosphere
4: hydrogen / palladium 10 on activated carbon / methanol / 20 °C
5: tetrahydrofuran / 18 h / 20 °C / Inert atmosphere; Reflux
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
C7H12N5O2S(1+)*CF3O3S(1-); triethylamine in neat (no solvent)
T=20°C; 0.0333333 h; Green chemistry;
参考文献
Muthyala, Manoj Kumar; Choudhary, Sunita; Kumar, Anil
Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8787 - 8791
反应条件
in chloroform
4 h; Heating;
参考文献
Kokel, Bruno; Viehe, Heinz Guenter
Angewandte Chemie, 1980 , vol. 92, # 9 p. 754 - 755
参考文献
Deb, Mohit L.; Bhuyan, Pulak J.
Tetrahedron Letters, 2007 , vol. 48, # 12 p. 2159 - 2163
反应条件
1: trichlorophosphate / water / 3 h / Reflux
2: hydroxylamine hydrochloride; sodium acetate / isopropyl alcohol / 4 h / Reflux
3: pyridine / 6 h / Reflux; Inert atmosphere
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/114184 A1, 2011 ;
WO 2011/114184 A1
反应条件
1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 18.08 h / 0 - 20 °C
2: acetic acid; sodium cyanoborohydride / 2 h / 20 °C
View Scheme
参考文献
Szostak, Michal; Sautier, Brice; Spain, Malcolm; Behlendorf, Maike; Procter, David J.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 48 p. 12559 - 12563
Angew. Chem., 2013 , vol. 125, # 48 p. 12791 - 12795,5
反应条件
1: 91 percent / acetic acid / 1 h / Heating
2: 94 percent / zinc dust; acetic acid / 20 °C
View Scheme
参考文献
Jursic, Branko S.; Neumann, Donna M.
Tetrahedron Letters, 2001 , vol. 42, # 25 p. 4103 - 4107
反应条件
triethylamine in chloroform
T=70°C;
参考文献
Krasnov; Kartsev; Gorovoi; Khrustalev
Chemistry of Natural Compounds, 2002 , vol. 38, # 5 p. 450 - 457
反应条件
1: water / 20 °C
2: 5 palladium on charcoal; hydrogen / methanol / 5 h / 20 °C / 1654.92 Torr
View Scheme
参考文献
Neumann, Donna M.; Cammarata, Amy; Backes, Gregory; Palmer, Glen E.; Jursic, Branko S.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 813 - 826
