2-[(二甲基氨基)甲基]环己酮合成路线 （共 38 条）
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 0.55 h; Inert atmosphere; optical yield given as percent de;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=55 - 120°C; 2: With lithium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=25°C; 0.5 h; 3: (RS)-2-dimethylaminomethyl-cyclohexanone With water; ammonium chloride Product distribution / selectivity; more than 3 stages;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 1; 8-9 ;
反应条件
in tetrahydrofuran stereoselective reaction;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 0.55 h; Inert atmosphere; optical yield given as percent de;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=55 - 120°C; 2: With lithium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=25°C; 0.5 h; 3: (RS)-2-dimethylaminomethyl-cyclohexanone With water; ammonium chloride Product distribution / selectivity; more than 3 stages;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 1; 8-9 ;
反应条件
in tetrahydrofuran stereoselective reaction;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 0.55 h; Inert atmosphere; optical yield given as percent de;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=55 - 120°C; 2: With lithium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=25°C; 0.5 h; 3: (RS)-2-dimethylaminomethyl-cyclohexanone With water; ammonium chloride Product distribution / selectivity; more than 3 stages;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 1; 8-9 ;
反应条件
in tetrahydrofuran stereoselective reaction;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
参考文献
Gill et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4923,4927
