(吡啶-4-甲基)磷酸二乙酯合成路线 （共 10 条）
反应条件
1: m-chloroperbenzoic acid / acetone / 4 h / Ambient temperature 2: 2) Me2NCOCl / 1) CH2Cl2, 5 min, rt, 2) rt, overnight 3: 76 percent / 6 N HCl / Heating View Scheme
参考文献
Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833
反应条件
1: 106 g / MCPBA / CH2Cl2 / 2 h / Ambient temperature 2: 88 percent / Et3N / 1 h / Heating 3: 71 percent / conc. H2SO4 / 0.17 h / 80 °C View Scheme
参考文献
Hutchison; Williams; Angst; De Jesus; Blanchard; Jackson; Wilusz; Murphy; Bernard; Schneider; Campbell; Guida; Sills
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2171 - 2178
反应条件
sodium hydroxide; sodium
1.) benzene, 2.) reflux, 2 h; Yield given. Multistep reaction;
参考文献
Okamoto, Yoshiki; Kokubo, Ichiro; Takamuku, Setsuo
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 8 p. 2438 - 2440
反应条件
1: 83 percent / SOCl2 / 3 h / Heating
2: 1.) Na / 1.) C6H6, reflux, 30 min, 2.) C6H6, 30 min
View Scheme
参考文献
Kaushik, Mahabir P.; Vaidyanathaswamy, Ramamoorthy
Phosphorus, Sulfur and Silicon and the Related Elements, 1995 , vol. 102, # 1-4 p. 45 - 50
反应条件
1: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C
2: thionyl chloride / dichloromethane / 3 h / 0 °C / |Reflux
3: sodium hydride / tetrahydrofuran
View Scheme
参考文献
Xue, Jian; Diao, Jiasheng; Cai, Guobin; Deng, Lisheng; Zheng, Baisong; Yao, Yuan; Song, Yongcheng
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 278 - 282
反应条件
sodium hydride in tetrahydrofuran
参考文献
Xue, Jian; Diao, Jiasheng; Cai, Guobin; Deng, Lisheng; Zheng, Baisong; Yao, Yuan; Song, Yongcheng
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 278 - 282
反应条件
1: 38 percent / LiAlH4 / diethyl ether / 0.5 h
2: 83 percent / SOCl2 / 3 h / Heating
3: 1.) Na / 1.) C6H6, reflux, 30 min, 2.) C6H6, 30 min
View Scheme
参考文献
Kaushik, Mahabir P.; Vaidyanathaswamy, Ramamoorthy
Phosphorus, Sulfur and Silicon and the Related Elements, 1995 , vol. 102, # 1-4 p. 45 - 50
反应条件
sodium hydride
1) THF, hexane, rt, 2 h, 2) THF, rt, overnight; Multistep reaction;
参考文献
Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833
反应条件
in benzene
2 h; Heating;
参考文献
Okamoto, Yoshiki; Kokubu, Ichiro; Takamuku, Setsuo
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 48, # 1-4 p. 63 - 67
反应条件
hydrogenchloride
8 h; Heating;
参考文献
Kostka, Krzysztof; Ochocki, Justyn
Polish Journal of Chemistry, 1987 , vol. 61, # 1-3 p. 177 - 188
