2,4,6-三甲基苯磺酰氯合成路线 （共 56 条）
反应条件
pyridine
1.) -28 deg C, 4 d, 2.) 0 deg C, 3 d;
参考文献
Guthrie, R. D. (Gus); Jenkins, Ian D.; Watters, James J.
Australian Journal of Chemistry, 1980 , vol. 33, # 11 p. 2487 - 2497
参考文献
Hanefeld; Landwehr
Pharmazie, 1995 , vol. 50, # 5 p. 344 - 351
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 4 h;
参考文献
GRUENENTHAL GmbH
Patent: US2009/186899 A1, 2009 ;
Location in patent: Page/Page column 24 ;
US 20090186899 A1
反应条件
1: Na2SO3*7H2O,NaHCO3 / H2O / 50 h / 70 - 80 °C
2: H2O / 168 h / 60 °C
3: 94 percent / NOCl / pyridine / 2 h / -15 - -10 °C
4: 78 percent / Al2O3 / diethyl ether; CH2Cl2 / 2 h / 0 °C
5: 82 percent / triethylamine / acetonitrile / 27 h / Ambient temperature
6: 32 percent / acetonitrile / 48 h / Heating
View Scheme
参考文献
Kuo, Ying-Che; Aoyama, Toyohiko; Shioiri, Takayuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 899 - 902
反应条件
1: 85 percent / pyridine / CHCl3 / 12 h / 20 °C
2: 34 percent Chromat. / dppfNiCl2 / tetrahydrofuran / 48 h / Heating
View Scheme
参考文献
Cho, Chul-Hee; Yun, Hee-Sung; Park, Kwangyong
Journal of Organic Chemistry, 2003 , vol. 68, # 8 p. 3017 - 3025
反应条件
aluminium trichloride
参考文献
Meyer,H.
Justus Liebigs Annalen der Chemie, 1923 , vol. 433, p. 342
