1-氨基-4-氯-2-丁炔合成路线 (共 7 条)
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in chloroform 18 h; Heating / reflux; 2: With hydrogenchloride in ethanol 18 h; Heating / reflux;
参考文献
US6344483 B1, ;
Page column 19 ;
反应条件
hydrogenchloride in ethanol; chloroform
反应条件
acetic anhydride in aqueous sodium acetate-solution; ethyl acetate
参考文献
Akzo Nobel N.V.
Patent: US6410684 B1, 2002 ;
反应条件
water; sodium acetate
参考文献
Marszak-Fleury
Annales de Chimie (Cachan, France), 1958 , vol. <13>3, p. 656,676
Bulletin de la Societe Chimique de France, 1958 , p. 490,492
反应条件
sodium hydroxide in 1,4-dioxane; water
2 h; Ambient temperature;
参考文献
Sasaki, Andre N.; Bricas, Evanghelos
Tetrahedron Letters, 1980 , vol. 21, p. 4263 - 4264
反应条件
1: 1-Amino-4-chloro-2-butyne hydrochloride With sodium hydroxide in 1,4-dioxane; water
0.5 h;
2: carbonic acid di-tert-butyl ester in trans-1,3-dioxane; water
T=20 - 25°C; 8 h;
参考文献
G. D. Searle and Co.
Patent: US6344483 B1, 2002 ;
Location in patent: Page column 19 ;
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; water
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1