(S)-1,2,3,4-四氢-3-异喹啉羧酸叔丁酯盐酸盐合成路线 （共 8 条）
反应条件
sodium hydroxide in water; toluene T=20°C; pH=8 - 9; 0.916667 h; Alkaline aqueous solution;
参考文献
US2004/192613 A1, ;
Page/Page column 5 ;
反应条件
hydrogen; palladium on activated charcoal in methanol 2 h; Ambient temperature;
参考文献
Salvadori, Severe; Balboni, Gianfranco; Guerrini, Remo; Tomatis, Roberto; Bianchi, Clementina; Bryant, Sharon D.; Cooper, Peter S.; Lazarus, Lawrence H.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3100 - 3108
反应条件
1: 74.7 percent / 1N NaOH / dimethylformamide / 27 h / 0 - 20 °C 2: 79 percent / conc. H2SO4 / CH2Cl2 / 360 h / Ambient temperature 3: 78 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 19 p. 3100 - 3108
反应条件
1: 79 percent / conc. H2SO4 / CH2Cl2 / 360 h / Ambient temperature 2: 78 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 19 p. 3100 - 3108
反应条件
sulfuric acid in 1,4-dioxane 24 h; Ambient temperature;
参考文献
Hayashi; Ozaki; Nunami; Uchida; Kato; Kinashi; Yoneda
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 570 - 576
反应条件
sulfuric acid in 1,4-dioxane 17 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 10 p. 1953 - 1961
反应条件
1: 78 percent / Et3N, DCC, 1-hydroxybenzotriazole / tetrahydrofuran / Ambient temperature 2: TFA / 1 h / Ambient temperature View Scheme
参考文献
Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961
反应条件
1: 78 percent / Et3N, DCC, 1-hydroxybenzotriazole / tetrahydrofuran / Ambient temperature 2: TFA / 1 h / Ambient temperature 3: 80 percent / AcOH / toluene / 0.5 h / 95 °C View Scheme
参考文献
Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961
