1: methyl [4-hydroxyphenyl]acetate With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 1 h; 2: 2-methyl-1-bromopropane in DMF (N,N-dimethyl-formamide) T=80°C; 72 h; 3: With hydrogenchloride; potassium hydroxide more than 3 stages;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2004/808 A2, 2003 ;
Location in patent: Page 37-38 ;
WO 2004/000808 A2