1: 3-Methylbenzonitrile With ammonia; lithium; tert-butyl alcohol in tetrahydrofuran
T=-35°C;
2: 2-methyl-1-bromopropane in tetrahydrofuran; ammonia
cooling; Further stages. Title compound not separated from byproducts.;
参考文献
Vaganova; Panteleeva; Yuferov; Rebitva; Shteingarts
Russian Chemical Bulletin, 2006 , vol. 55, # 6 p. 981 - 986
tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=60°C; 8 h;
参考文献
Xie, Hui; Ng, Danny; Savinov, Sergey N.; Dey, Barna; Kwong, Peter D.; Wyatt, Richard; Smith III, Amos B.; Hendrickson, Wayne A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 20 p. 4898 - 4908
