3-溴-5-甲氧基吡啶-1-氧化物合成路线 （共 11 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine; 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide in dichloromethane T=0 - 5°C; 2: With p-toluenesulfonyl chloride in dichloromethane T=0 - 20°C; 3: With sulfuric acid in dichloromethane; water T=60 - 70°C;
参考文献
Farrell, Robert P.; Elipe, Maria Victoria Silva; Bartberger, Michael D.; Tedrow, Jason S.; Vounatsos, Filisaty
Organic Letters, 2013 , vol. 15, # 1 p. 168 - 171
反应条件
1: sulfuric acid; potassium nitrate / 35 °C 2: iron-powder; acetic acid / 100 °C View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1171,1174
反应条件
trichlorophosphate in chloroform Meisenheimer rearrangement;
参考文献
Tetrahedron, , vol. 65, # 4 p. 757 - 764
反应条件
1: 95 percent / aq. NH3, CuSO4 / 5 h / 130 °C 2: 95 percent / H2 / Raney-Ni / methanol / 1 h / Ambient temperature View Scheme
参考文献
Tamura, Yasumitsu; Fujita, Masanobu; Chen, Ling Ching; Kiyokawa, Hiroshi; Ueno, Kyoji; Kita, Yasuyuki
Heterocycles, 1981 , vol. 15, # 2 p. 871 - 874
反应条件
1: trichlorophosphate / chloroform / 7 h / Reflux; Inert atmosphere; Cooling with ice 2: 7 h / Inert atmosphere; Reflux View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2426135 A1, 2012 ;
反应条件
dihydrogen peroxide; methyltrioxorhenium (VII) in dichloromethane; water
T=25°C; Inert atmosphere;
参考文献
Morgentin, Remy; Jung, Frederic; Lamorlette, Maryannick; Maudet, Mickael; Menard, Morgan; Ple, Patrick; Pasquet, Georges; Renaud, Fabrice
Tetrahedron, 2009 , vol. 65, # 4 p. 757 - 764
反应条件
in dichloromethane
T=20°C; 3 h; Inert atmosphere;
参考文献
Parhi, Ajit K.; Xiang, Amy; Bauman, Joseph D.; Patel, Disha; Vijayan; Das, Kalyan; Arnold, Eddy; Lavoie, Edmond J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6435 - 6446
反应条件
potassium hydroxide
0.5 h; Heating;
参考文献
Tamura, Yasumitsu; Fujita, Masanobu; Chen, Ling Ching; Kiyokawa, Hiroshi; Ueno, Kyoji; Kita, Yasuyuki
Heterocycles, 1981 , vol. 15, # 2 p. 871 - 874
反应条件
1: copper-powder; sodium methylate; methanol
2: chloroform
View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1171,1174
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1171,1174
