1-Cbz-3-哌啶甲酸合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane
参考文献
Taylor, G. Mark; Baker, Stewart J.; Gedney, Andrea; Pearson, David J.; Sibley, Graham E. M.
Tetrahedron Letters, 1996 , vol. 37, # 8 p. 1297 - 1300
反应条件
sodium hydroxide in 1,4-dioxane; hexane
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 5 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1553074 A1, 2005 ;
Location in patent: Page/Page column 41 ;
反应条件
hydrogenchloride Yield given;
参考文献
Taylor, G. Mark; Baker, Stewart J.; Gedney, Andrea; Pearson, David J.; Sibley, Graham E. M.
Tetrahedron Letters, 1996 , vol. 37, # 8 p. 1297 - 1300
反应条件
1: HCl 2: 90 percent / LiN(TMS)2, DMPU / tetrahydrofuran / -60 °C / to room temperature 3: 78 percent / NaOH / tetrahydrofuran; H2O View Scheme
参考文献
Taylor, G. Mark; Baker, Stewart J.; Gedney, Andrea; Pearson, David J.; Sibley, Graham E. M.
Tetrahedron Letters, 1996 , vol. 37, # 8 p. 1297 - 1300
反应条件
boron trifluoride diethyl etherate in tetrahydrofuran T=20°C; 18 h;
参考文献
Abbott Laboratories
Patent: US2004/116518 A1, 2004 ;
Location in patent: Page 117 ;
反应条件
thionyl chloride in dichloromethane 1.5 h; Heating;
参考文献
Boxus, Thierry; Touillaux, Roland; Dive, Georges; Marchand-Brynaert, Jacqueline
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1577 - 1595
反应条件
1: HCl
2: 90 percent / LiN(TMS)2, DMPU / tetrahydrofuran / -60 °C / to room temperature
View Scheme
参考文献
Taylor, G. Mark; Baker, Stewart J.; Gedney, Andrea; Pearson, David J.; Sibley, Graham E. M.
Tetrahedron Letters, 1996 , vol. 37, # 8 p. 1297 - 1300
反应条件
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 - 20 °C
2: diethyl ether / 0 - 20 °C
View Scheme
参考文献
Kalypsys, Inc
Patent: US8080566 B1, 2011 ;
反应条件
1: (6-chloro-pyridazine-3-yl)-hydrazine; 1-[(benzyloxy)carbonyl]-3-piperidinecarboxylic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 16 h;
2: With acetic acid
T=110°C; 48 h;
3: piperidine With hydrogen; palladium 10 on activated carbon
more than 3 stages;
参考文献
Astellas Pharma Inc.
Patent: EP1640010 A1, 2006 ;
Location in patent: Page/Page column 18 ;
