1: 1.) sodium nitrite, conc. HCl 2.) sodium azide / 1.) water 2: 2.4 percent / various solvent(s) / 4 h / 185 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a> <br />4&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 66 percent / 30percent hydrogen peroxide / acetic acid / 1.) 55-60 deg C, 2 h, 2.) 75-80 deg C, 15 h<br />2: 85 percent / 10percent aq. sodium hydroxide / 4 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: 75 percent / n-butyl-lithium / hexane; diethyl ether / 1.) -70 deg C, 2 h, 2.) room temperature, 2 h<br />2: 98 percent / hydrogen / 10percent palladium-charcoal / aq. ethanol<br />3: 86 percent / hydrogen, conc. hydrochloric acid / 10percent palladium-charcoal / ethanol / 20 h / Ambient temperature<br />4: 81 percent / H₂O / 0 &deg;C<br />5: 66 percent / 30percent hydrogen peroxide / acetic acid / 1.) 55-60 deg C, 2 h, 2.) 75-80 deg C, 15 h<br />6: 85 percent / 10percent aq. sodium hydroxide / 4 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: 75 percent / n-butyl-lithium / hexane; diethyl ether / 1.) -70 deg C, 2 h, 2.) room temperature, 2 h<br />2: 98 percent / hydrogen / 10percent palladium-charcoal / aq. ethanol<br />3: 86 percent / hydrogen, conc. hydrochloric acid / 10percent palladium-charcoal / ethanol / 20 h / Ambient temperature<br />4: 81 percent / H₂O / 0 &deg;C<br />5: 66 percent / 30percent hydrogen peroxide / acetic acid / 1.) 55-60 deg C, 2 h, 2.) 75-80 deg C, 15 h<br />6: 85 percent / 10percent aq. sodium hydroxide / 4 h / Heating<br /> <br /> &nbsp;