5-氯-2-哌啶-1-基-1,3-苯并恶唑合成路线 （共 7 条）
反应条件
triphenylphosphine; copper(l) chloride; lithium tert-butylate in tetrahydrofuran
T=20°C; 1 h;
参考文献
Yotphan, Sirilata; Beukeaw, Danupat; Reutrakul, Vichai
Tetrahedron, 2013 , vol. 69, # 32 p. 6627 - 6633
反应条件
1: trifluorormethanesulfonic acid / acetonitrile / 6 h / 60 °C
2: 2,2,6,6-tetramethyl-piperidine; TEMPO+BF4- / acetonitrile / 0.25 h / 60 °C
View Scheme
参考文献
Wertz, Sebastian; Kodama, Shintaro; Studer, Armido
Angewandte Chemie - International Edition, 2011 , vol. 50, # 48 p. 11511 - 11515
反应条件
1: 4 h / 160 °C
2: trifluorormethanesulfonic acid / acetonitrile / 6 h / 60 °C
3: 2,2,6,6-tetramethyl-piperidine; TEMPO+BF4- / acetonitrile / 0.25 h / 60 °C
View Scheme
参考文献
Wertz, Sebastian; Kodama, Shintaro; Studer, Armido
Angewandte Chemie - International Edition, 2011 , vol. 50, # 48 p. 11511 - 11515
反应条件
1: dipotassium hydrogenphosphate / N,N-dimethyl-formamide / 1 h / 20 °C
2: copper(l) chloride; triphenylphosphine; lithium tert-butylate / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Yotphan, Sirilata; Beukeaw, Danupat; Reutrakul, Vichai
Tetrahedron, 2013 , vol. 69, # 32 p. 6627 - 6633
反应条件
in tetrahydrofuran
T=20°C; 1 h;
参考文献
Yotphan, Sirilata; Beukeaw, Danupat; Reutrakul, Vichai
Synthesis (Germany), 2013 , vol. 45, # 7 art. no. SS-2013-F0068-OP, p. 936 - 942
反应条件
1: aq. NaOH
2: Heating
View Scheme
参考文献
Sam,J.; Plampin,J.N.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 538 - 544
参考文献
Sam,J.; Plampin,J.N.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 538 - 544
