(S)-乙酰基氨基环己基乙酸合成路线 （共 13 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
P=1520 Torr; 2 h;
参考文献
Santoso, Sentot; Kemmer, Thorsten; Trowitzsch, Wolfram
Liebigs Annalen der Chemie, 1981 , # 4 p. 642 - 657
反应条件
sodium hydroxide in water
T=0°C; 2 h;
参考文献
MEDIVIR UK LIMITED; AYESA, Susana; CARLQUIST, Peter; ERSMARK, Karolina; GRABOWSKA, Urszula; HEWITT, Ellen; JOeNSSON, Daniel; KAHNBERG, Pia; KLASSON, Bjoern; LIND, Peter; ODEN, Lourdes; PARKES, Kevin; WIKTELIUS, Daniel
Patent: WO2011/70541 A1, 2011 ;
Location in patent: Page/Page column 42-43 ;
反应条件
sulfuric acid; lithium bromide; [PdBr2(PPh3)2] in various solvent(s)
T=120°C; P=45003.6 Torr; 12 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Beller, Matthias; Eckert, Markus; Geissler, Holger; Napierski, Bernd; Rebenstock, Heinz-Peter; Holla, E. Wolfgang
Chemistry - A European Journal, 1998 , vol. 4, # 5 p. 935 - 941
反应条件
[Rh((R,R)-Cy-SMS-Phos)(MeOH)2]BF4; hydrogen in methanol
T=20°C; P=750.075 Torr; 4 h; optical yield given as percent ee;
参考文献
Zupancic, Borut; Mohar, Barbara; Stephan, Michel
Organic Letters, 2010 , vol. 12, # 13 p. 3022 - 3025
反应条件
ruthenium trichloride; periodic acid in tetrachloromethane; water; acetonitrile
T=20°C; 48 h;
参考文献
Hasegawa, Masayoshi; Taniyama, Daisuke; Tomioka, Kiyoshi
Tetrahedron, 2000 , vol. 56, # 52 p. 10153 - 10158
反应条件
hydrogen; palladium on activated charcoal in methanol
P=1520 Torr; 2 h;
参考文献
Santoso, Sentot; Kemmer, Thorsten; Trowitzsch, Wolfram
Liebigs Annalen der Chemie, 1981 , # 4 p. 642 - 657
反应条件
1: N,N'-Carbonyldiimidazol / toluene / 48 h / Ambient temperature
2: 7.3 mg / 3.5 N H2SO4 / dioxane / 2 h / Heating
3: 7.3 mg / H2 / Pd/C / methanol / 2 h / 1520 Torr
View Scheme
参考文献
Santoso, Sentot; Kemmer, Thorsten; Trowitzsch, Wolfram
Liebigs Annalen der Chemie, 1981 , # 4 p. 642 - 657
反应条件
1: 91 percent / triethylamine / H2O / 0.5 h / 0 °C
2: N,N'-Carbonyldiimidazol / toluene / 48 h / Ambient temperature
3: 7.3 mg / 3.5 N H2SO4 / dioxane / 2 h / Heating
4: 7.3 mg / H2 / Pd/C / methanol / 2 h / 1520 Torr
View Scheme
参考文献
Santoso, Sentot; Kemmer, Thorsten; Trowitzsch, Wolfram
Liebigs Annalen der Chemie, 1981 , # 4 p. 642 - 657
反应条件
1: 7.3 mg / 3.5 N H2SO4 / dioxane / 2 h / Heating
2: 7.3 mg / H2 / Pd/C / methanol / 2 h / 1520 Torr
View Scheme
参考文献
Santoso, Sentot; Kemmer, Thorsten; Trowitzsch, Wolfram
Liebigs Annalen der Chemie, 1981 , # 4 p. 642 - 657
反应条件
1: (R,R)-dimethoxydiphenylethane / cyclohexane; diethyl ether; toluene / 0.7 h / -45 °C
2: cerium(IV) diammonium nitrate / acetonitrile; H2O / 2.5 h / 0 - 20 °C
3: aq. NaOH / acetonitrile / 1 h / 0 °C
4: 53 percent / RuCl3 hydrate; HIO4 / CCl4; acetonitrile; H2O / 48 h / 20 °C
View Scheme
参考文献
Hasegawa, Masayoshi; Taniyama, Daisuke; Tomioka, Kiyoshi
Tetrahedron, 2000 , vol. 56, # 52 p. 10153 - 10158
