(S)-乙酰基氨基环己基乙酸合成路线 （共 13 条）
反应条件
1: cerium(IV) diammonium nitrate / acetonitrile; H2O / 2.5 h / 0 - 20 °C
2: aq. NaOH / acetonitrile / 1 h / 0 °C
3: 53 percent / RuCl3 hydrate; HIO4 / CCl4; acetonitrile; H2O / 48 h / 20 °C
View Scheme
参考文献
Hasegawa, Masayoshi; Taniyama, Daisuke; Tomioka, Kiyoshi
Tetrahedron, 2000 , vol. 56, # 52 p. 10153 - 10158
反应条件
1: 2.20 g / MgSO4 / CHCl3 / 2 h / 20 °C
2: (R,R)-dimethoxydiphenylethane / cyclohexane; diethyl ether; toluene / 0.7 h / -45 °C
3: cerium(IV) diammonium nitrate / acetonitrile; H2O / 2.5 h / 0 - 20 °C
4: aq. NaOH / acetonitrile / 1 h / 0 °C
5: 53 percent / RuCl3 hydrate; HIO4 / CCl4; acetonitrile; H2O / 48 h / 20 °C
View Scheme
参考文献
Hasegawa, Masayoshi; Taniyama, Daisuke; Tomioka, Kiyoshi
Tetrahedron, 2000 , vol. 56, # 52 p. 10153 - 10158
反应条件
1: dichloromethane / 0.5 h / 0 °C
2: sodium hydroxide / water / 2 h / 0 °C
View Scheme
参考文献
MEDIVIR UK LIMITED; AYESA, Susana; CARLQUIST, Peter; ERSMARK, Karolina; GRABOWSKA, Urszula; HEWITT, Ellen; JOeNSSON, Daniel; KAHNBERG, Pia; KLASSON, Bjoern; LIND, Peter; ODEN, Lourdes; PARKES, Kevin; WIKTELIUS, Daniel
Patent: WO2011/70541 A1, 2011 ;
