3-(羟基甲基)苯基乙酸酯合成路线 （共 8 条）
反应条件
potassium hydroxide in water
Acetylation; 0.75 h;
参考文献
Guo, Zhao-Xia; Cammidge, Andrew N.; Horwell, David C.
Tetrahedron, 2000 , vol. 56, # 29 p. 5169 - 5175
反应条件
chloro-trimethyl-silane; nickel boride; Cholestanone in diethylene glycol dimethyl ether; N,N-dimethyl-formamide
1 h; Ambient temperature;
参考文献
Borbaruah, M.; Barua, N. C.; Sharma, R. P.
Tetrahedron Letters, 1987 , vol. 28, # 46 p. 5741 - 5742
反应条件
acetic anhydride in potassium hydroxide
参考文献
LABORATORIO FARMACEUTICO C.T. S.r.l.
Patent: EP579129 A2, 1994 ;
反应条件
RbF in acetonitrile
T=80°C; 0.416667 h;
参考文献
Miyazawa, Toshifumi; Yamamoto, Masato; Danjo, Hiroshi
Monatshefte fur Chemie, 2013 , vol. 144, # 9 p. 1351 - 1354
反应条件
1: Et3N / tetrahydrofuran / 20 °C
2: NaBH4 / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
反应条件
triethylamine in ethyl acetate
T=0 - 20°C; 6 h;
参考文献
Kodela, Ravinder; Chattopadhyay, Mitali; Nath, Niharika; Cieciura, Lucyna Z.; Pospishill, Liliya; Boring, Daniel; Crowell, James A.; Kashfi, Khosrow
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 7146 - 7150
反应条件
pyridine; thionyl chloride in toluene
1 h; Heating;
参考文献
Hulsman, Niels; Medema, Jan Paul; Bos, Carina; Jongejan, Aldo; Leurs, Rob; Smit, Martine J.; De Esch, Iwan J. P.; Richel, Dick; Wijtmans, Maikel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2424 - 2431
反应条件
phosphorus tribromide in toluene
Substitution; 1.5 h;
参考文献
Guo, Zhao-Xia; Cammidge, Andrew N.; Horwell, David C.
Tetrahedron, 2000 , vol. 56, # 29 p. 5169 - 5175
