1: 4-bromobenzyl-alcohol With sodium hydride in tetrahydrofuran
T=0°C; 1 h;
2: monobromoacetic acid in tetrahydrofuran
3 h; Heating / reflux;
3: With hydrogenchloride; water
pH=2;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2007/76431 A1, 2007 ;
Location in patent: Page/Page column 224 ;
WO 2007/076431 A1
Atmaram, Shiravanate; Forrester, Alexander R.; Gill, Melvyn; Napier, Russell J.; Thomson, Ronald H.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 9 p. 641 - 648