1: pyridine-2-carboxylic acid With benzotriazol-1-ol; diisopropyl-carbodiimide in tetrahydrofuran T=20°C; 2: thiosemicarbazide in tetrahydrofuran T=100°C; 0.0833333 h; microwave irradiation; 3: With sodium hydroxide in ethanol; water T=150°C; 0.166667 h; microwave irradiation;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/87218 A1, 2009 ;
Location in patent: Page/Page column 39 ;
WO 2009/087218 A1