2-丁基-4-氯-5-(羟甲基)咪唑合成路线 （共 32 条）
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; N-chloro-succinimide; sodium hydrogencarbonate in water; toluene T=20°C;
参考文献
Miller, Ross A; Hoerrner, R Scott
Organic letters, 2003 , vol. 5, # 3 p. 285 - 287
反应条件
1: With potassium carbonate in N,N-dimethyl acetamide T=0 - 20°C; 2: With sodium tetrahydroborate in N,N-dimethyl acetamide; water T=20°C; 3 h;
参考文献
WO2004/66997 A2, ;
Page/Page column 46-47 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 10 h;
参考文献
Sieron, Leslaw; Nagaraj; Prabhuswamy; Yathirajan; Nagaraja; Narasegowda; Gaonkar
Acta Crystallographica Section C: Crystal Structure Communications, 2004 , vol. 60, # 11 p. o821-o823
反应条件
1: K2CO3 / N,N-dimethyl-acetamide View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
potassium carbonate in N,N-dimethyl-formamide Ambient temperaturevarious ratios of reagents; Product distribution;
参考文献
Pierce, Michael E.; Carini, David J.; Huhn, George F.; Wells, Gregory J.; Arnett, John F.
Journal of Organic Chemistry, 1993 , vol. 58, # 17 p. 4642 - 4645
反应条件
1: 77 percent / 1.0 N aq. ceric ammonium nitrate / acetic acid / 3 h / 25 °C 2: 49 percent / potassium carbonate / dimethylformamide / 24 h / 25 °C 3: 10percent HCl / tetrahydrofuran / 4 h / 25 °C View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 77 percent / 1.0 N aq. ceric ammonium nitrate / acetic acid / 3 h / 25 °C 2: 49 percent / potassium carbonate / dimethylformamide / 24 h / 25 °C 3: sodium borohydride / CH2Cl2 / 24 h / 25 °C 4: 89 percent / 10percent HCl / tetrahydrofuran / 4 h / 25 °C View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
2: 62 percent / 2.5 N NaOH / methanol / 20 h / 25 °C View Scheme
参考文献
Bovy, P. R.; Collins, J. T.; Olins, G. M.; McMahon, E. G.; Hutton, W. C.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2410 - 2414
反应条件
2: 80 percent / 2.5 N NaOH / methanol / 20 h / 25 °C View Scheme
参考文献
Bovy, P. R.; Collins, J. T.; Olins, G. M.; McMahon, E. G.; Hutton, W. C.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2410 - 2414
反应条件
potassium carbonate in N,N-dimethyl acetamide
参考文献
Larsen; King; Chen; Corley; Foster; Roberts; Yang; Lieberman; Reamer; Tschaen; Verhoeven; Reider; Lo; Rossano; Brookes; Meloni; Moore; Arnett
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6391 - 6394
