N,N-二乙基-4-羟基苯甲酰胺合成路线 （共 21 条）
反应条件
diethyl ether; anhydrous butyl ether Erhitzen des vom Diaethylaether befreiten Reaktionsgemisches auf Siedetemperatur und anschliessende Hydrolyse;
参考文献
Couturier
Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597
参考文献
Couturier
Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597
反应条件
1: dibutyl ether; diethyl ether / Erhitzen des vom Diaethylaether befreiten Reaktionsgemisches auf Siedetemperatur und anschliessende Hydrolyse View Scheme
参考文献
Couturier
Annales de Chimie (Cachan, France), 1938 , vol. <11> 10, p. 559,597
反应条件
1: aq. NaOH solution 2: benzene; diethyl ether View Scheme
参考文献
Annales de Chimie (Cachan, France), , vol. <11> 10, p. 559,597
反应条件
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 20 h; Inert atmosphere;
参考文献
COATS, STEVEN J.; Zhang, Yue-Mei; Lin, Shu-Chen; Liu, Li; Miskowski, Tamara A.; Dax, Scott L.; Breslin, Henry; De Corte, Bart L.; He, Wei
Patent: US2011/105455 A1, 2011 ;
Location in patent: Page/Page column 24 ;
反应条件
cesium hydroxide monohydrate; t-Bu Brett Phos; C44H62NO5PPdS; water in 1,4-dioxane
T=20°C; 18 h; Inert atmosphere;
参考文献
Cheung, Chi Wai; Buchwald, Stephen L.
Journal of Organic Chemistry, 2014 , vol. 79, # 11 p. 5351 - 5358
反应条件
n-butyllithium in tetrahydrofuran; diethyl ether; hexane; ethyl acetate
参考文献
Zeneca Limited
Patent: US5866611 A1, 1999 ;
反应条件
1: 4-hydroxy benzoyl chloride; diethylamine in dichloromethane
1 h;
2: diethylamine 18 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2005/61484 A1, 2005 ;
Location in patent: Page/Page column 44 ;
WO 2005/061484 A1
反应条件
boron tribromide in dichloromethane
T=-78°C;
参考文献
Billedeau, R.J.; Sibi, M.P.; Snieckus, V.
Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4515 - 4518
反应条件
1-hydroxybut-2-yne; potassium tert-butylate in dimethyl sulfoxide
T=125°C; 0.25 h; Microwave irradiation;
参考文献
Mittapalli, Gopi Kumar; Vellucci, Danielle; Yang, Jun; Toussaint, Marion; Brothers, Shaun P.; Wahlestedt, Claes; Roberts, Edward
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3916 - 3920
