4-(3,4-二氯苯基)-1-四氢萘酮合成路线 （共 39 条）
反应条件
1: chiral HPLC / Resolution of racemate 2: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 3: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 4: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme
参考文献
Chen, Fei; Ding, Ziyuan; He, Yanmei; Qin, Jie; Wang, Tianli; Fan, Qing-Hua
Tetrahedron, 2012 , vol. 68, # 26 p. 5248 - 5257
反应条件
in ethanol T=0°C; HeatingIndustrial scaleLarge scale; Solvent;
参考文献
Taber, Geraldine P.; Pfisterer, David M.; Colberg, Juan C.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 385 - 388
反应条件
methanesulfonic acid in ethanol T=0 - 70°C; 4 h;
参考文献
Ciba Specialty Chemicals Corporation
Patent: US6693218 B1, 2004 ;
Location in patent: Page column 12 ;
反应条件
methanesulfonic acid in ethanol T=0 - 70°C; 4 h;
参考文献
Ciba Specialty Chemicals Corporation
Patent: US6693218 B1, 2004 ;
Location in patent: Page column 14 ;
反应条件
formic acid; methylamine in N,N-dimethyl-formamide
参考文献
ORION COPRORATION FERMION
Patent: US2003/13768 A1, 2003 ;
反应条件
1: With triethylammonium formate; magnesium sulfate T=125 - 145°C; 16 h; 2: With hydrogenchloride in water; isopropyl alcohol 6 h; Heating / reflux;
参考文献
STOHANDL, Jiri FRANTISEK, Jaroslav; ZAPADLO, Zdenek; STOHANDLOVA, Marta
Patent: WO2003/99761 A1, 2003 ;
Location in patent: Page 4; 11 ;
反应条件
1: TiCl4 / toluene / 17 h / Ambient temperature 2: sodium borohydride / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Taber, Geraldine P.; Pfisterer, David M.; Colberg, Juan C.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 385 - 388
反应条件
1: titanium tetraethoxide / tetrahydrofuran; ethanol / 70 °C / |Inert atmosphere; |Large scale 2: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran; toluene / -10 - 5 °C / |Inert atmosphere; |Large scale 3: hydrogenchloride / tetrahydrofuran; toluene; methanol / |Inert atmosphere; |Large scale View Scheme
参考文献
Han, Zhengxu; Koenig, Stefan G.; Zhao, Hang; Su, Xiping; Singh, Surendra P.; Bakale, Roger P.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 726 - 730
反应条件
1: BH3*Me2S / (S)-prolinol core-containing second-generation dendrimer / tetrahydrofuran / 0.8 h 2: PCC / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Chen, Fei; Ding, Ziyuan; He, Yanmei; Qin, Jie; Wang, Tianli; Fan, Qing-Hua
Tetrahedron, 2012 , vol. 68, # 26 p. 5248 - 5257
反应条件
chiral HPLC Resolution of racemate; optical yield given as percent ee;
参考文献
Chen, Fei; Wang, Tianli; He, Yanmei; Ding, Ziyuan; Li, Zhiwei; Xu, Lijin; Fan, Qing-Hua
Chemistry - A European Journal, 2011 , vol. 17, # 4 p. 1109 - 1113
