4-溴甲基-5-甲基-1,3-间二氧杂环戊烯-2-酮合成路线 (共 17 条)
反应条件
potassium hydrogencarbonate 3 h; also in presence of DIPEA, car. concn. of substrates; Product distribution;
参考文献
Fujii; Nishida; Abiru; Yamamoto; Kise
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 11 p. 1872 - 1877
反应条件
1: 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole; N-alkylation of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate With tert-butylamine hydrobromide; potassium carbonate in acetone T=0 - 55°C; 32 h; 2: (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl bromide With potassium carbonate; potassium iodide in acetone T=20 - 55°C; 3 h;
参考文献
HETERO RESEARCH FOUNDATION; Parthasaradhi Reddy, Bandi; Rathnakar Reddy, Kura; Muralidhara Reddy, Dasari; Raji Reddy, Rapolu; Ramakrishna Reddy, Matta; Vamsi Krishna, Bandi
Patent: US2013/190506 A1, 2013 ;
Location in patent: Paragraph 0050 ;
反应条件
potassium carbonate; potassium iodide in acetone T=50 - 55°C; 3 h;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2012/1694 A1, 2012 ;
Location in patent: Page/Page column 9-10 ;
反应条件
potassium iodide in acetone
Ambient temperature;
参考文献
Sakamoto; Ikeda; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 6 p. 2241 - 2248
反应条件
in N-methyl-acetamide; water
参考文献
Kanebo Ltd.
Patent: US4455310 A1, 1984 ;
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide
5 h;
参考文献
Sakamoto; Ikeda; Kondo; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4870 - 4877
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2005/97760 A1, 2005 ;
Location in patent: Page/Page column 85; 24/24 ;