2,3,4,6-O-四特戊酰基-alpha-D-溴代吡喃葡萄糖合成路线 （共 10 条）
反应条件
1: With zinc dibromide in dichloromethane T=20°C; 0.166667 h; Inert atmosphere; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
US2011/87017 A1, ;
Page/Page column 34 ;
反应条件
BiBr3; trimethylsilyl bromide in dichloromethane T=20°C; 24 h;
参考文献
Presser, Armin; Kunert, Olaf; Poetschger, Irmgard
Monatshefte fur Chemie, 2006 , vol. 137, # 3 p. 365 - 374
反应条件
1: 73 percent / Et3N; DMAP / CH2Cl2 / 24 h / 20 °C 2: 97 percent / BiBr3; Me3SiBr / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Monatshefte fur Chemie, , vol. 137, # 3 p. 365 - 374
反应条件
1.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20.5 h / 0 - 20 °C / Inert atmosphere 2.1: trimethylsilyl bromide / zinc dibromide / dichloromethane / 24 h / 20 °C / Inert atmosphere 2.2: 0 °C / pH 7 - 8 View Scheme
参考文献
WO2012/140120 A1, ;
WO 2012/140120 A1
反应条件
hydrogen bromide; acetic acid in dichloromethane Molecular sieve;
参考文献
Synlett, , # 16 p. 2609 - 2612
反应条件
1.1: n-butyllithium; zinc dibromide / n-heptane; toluene; anhydrous butyl ether / 2.5 h / -10 - 25 °C / Inert atmosphere 1.2: 6.5 h / 95 °C 2.1: methanol / sodium methylate / 16 h / 60 °C View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; HOUPIS, Ioannis, Nicolaos; LEMAIRE, Sebastien, Francois, Emmanuel
Patent: WO2012/140120 A1, 2012 ;
WO 2012/140120 A1
反应条件
1: 89 percent / Ag2CO3, MS / diethyl ether 2: NaOMe 3: 72 percent / ion exchange resin / H2O View Scheme
参考文献
Adasch, Volker; Hoffmann, Bettina; Milius, Wolfgang; Platz, Gerhard; Voss, Gundula
Carbohydrate Research, 1998 , vol. 314, # 3-4 p. 177 - 187
反应条件
1: 80 percent / Ag2CO3, MS / diethyl ether / 24 h / Ambient temperature 2: 15.8 g / NaOMe / 24 h / Ambient temperature 3: 79 percent / ion exchange resin / methanol / 1 h / Ambient temperature View Scheme
参考文献
Adasch, Volker; Hoffmann, Bettina; Milius, Wolfgang; Platz, Gerhard; Voss, Gundula
Carbohydrate Research, 1998 , vol. 314, # 3-4 p. 177 - 187
反应条件
1: 85 percent / Ag2CO3, MS / diethyl ether 2: NaOMe 3: 87 percent / ion exchange resin / H2O View Scheme
参考文献
Carbohydrate Research, , vol. 314, # 3-4 p. 177 - 187
反应条件
1: 93 percent / Ag2O / quinoline / 0.25 h / Ambient temperature 2: 67 percent / CH3ONa / methanol / 48 h View Scheme
参考文献
Harreus; Kunz
1986 , vol. 1986, # 4 p. 717 - 730
