(三氟甲基)三甲基硅烷合成路线 （共 455 条）
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h; 2: With tetrabutyl ammonium fluoride in N,N-dimethyl-formamide 4 h;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
N-(EtOCH2CH2OCH2)-N-methylmorpholinium bis(CF3SO2)amide; cesium fluoride T=25°C; 0.5 h;
参考文献
Kim, Jinwi; Shreeve, Jean'ne M.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 19 p. 2728 - 2734
反应条件
hydrogenchloride; tetrabutyl ammonium fluoride 1) THF, 0 deg C - rt; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Prakash, G. K. Surya; Krishnamurti, Ramesh; Olah, George A.
Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 393 - 395
反应条件
1: 3-fluorobenzenecarboxaldehyde With N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide; (1,3-bis(2',6'-di-iso-propylphenyl)imidazol-2-ylidene)CuF in toluene T=-78°C; 0.166667 h; Inert atmosphere; 2: (trifluoromethyl)-trimethylsilane in toluene T=-78°C; 2 h; Inert atmosphere; 3: With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; Inert atmosphere; Overall yield = 87 percent; enantioselective reaction;
参考文献
Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue
Journal of Fluorine Chemistry, 2013 , vol. 148, p. 19 - 29
反应条件
1: in tetrahydrofuran T=0°C; 0.166667 h; Inert atmosphereSealed tube; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran T=0 - 20°C; Inert atmosphereSealed tube; 3: With tetrabutyl ammonium fluoride; water in tetrahydrofuran T=0 - 20°C; Inert atmosphereSealed tube;
参考文献
Kelly, Christopher B.; Mercadante, Michael A.; Hamlin, Trevor A.; Fletcher, Madison H.; Leadbeater, Nicholas E.
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8131 - 8141
反应条件
cesium hydroxide monohydrate in Solkane® 365mfc T=20°C; 2 h; Inert atmosphere;
参考文献
Kusuda, Akihiro; Kawai, Hiroyuki; Nakamura, Shuichi; Shibata, Norio
Green Chemistry, 2009 , vol. 11, # 11 p. 1733 - 1735
反应条件
1,10-phenanthroline; oxygen; copper diacetate; cesium fluoride in iso-butyronitrile T=20°C; Chan-Lam-type reaction; P=760.051 Torr; 3 h; Molecular sieveInert atmosphere;
参考文献
Senecal, Todd D.; Parsons, Andrew T.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1174 - 1176
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide T=20°C; 5 h;
参考文献
GLAXO GROUP LIMITED; AMANTINI, David; DI FABIO, Romano
Patent: WO2010/122151 A1, 2010 ;
Location in patent: Page/Page column 61-62 ;
WO 2010/122151 A1
反应条件
potassium fluoride; copper(l) iodide; 1,10-phenanthroline in N,N-dimethyl-formamide T=100°C; 6 h;
参考文献
Chu, Lingling; Qing, Feng-Ling
Journal of the American Chemical Society, 2010 , vol. 132, # 21 p. 7262 - 7263
反应条件
1: With cesium fluoride in ethylene glycol dimethyl ether T=20°C; 18 h; 2: With tetrabutyl ammonium fluoride; acetic acid in tetrahydrofuran T=20°C; 3 h;
参考文献
VIROBAY, INC.
Patent: WO2009/55467 A2, 2009 ;
Location in patent: Page/Page column 44 ;
WO 2009/055467 A2
