2,2,4,4-四甲基-3-戊酮合成路线 （共 175 条）
反应条件
oxygen in decane T=323°C; Irradiationother temperatures: 348, 373, 398 K; Product distributionMechanismKinetics;
参考文献
Costello, Andrew R.; Lindsay Smith, John R.; Stark, Moray S.; Waddington, David J.
Journal of the Chemical Society - Faraday Transactions, 1996 , vol. 92, # 19 p. 3497 - 3507
参考文献
Freidlin; Lebedewa
Zhurnal Obshchei Khimii, 1939 , vol. 9, p. 1589,1593
Chem. Zentralbl., 1941 , vol. 112, # I p. 511
反应条件
1: (i) nBuLi, (ii) /BRN= 1701122/
2: Heating
View Scheme
参考文献
Lomas,J.S. et al.
Journal of Organic Chemistry, 1977 , vol. 42, # 21 p. 3394 - 3399
反应条件
1: 1.) n-C4H9Li / 1.) THF, -110 deg C; 2.) room temp., 1.5 h
2: tetrahydrofuran; toluene / Heating
3: 82 percent / NBS / CH2Cl2 / Irradiation
4: 79 percent / Zn / tetrahydrofuran / 15 h / Ambient temperature
View Scheme
参考文献
Newman,M.S. et al.
Journal of the American Chemical Society, 1960 , vol. 82, p. 2498 - 2501
反应条件
in tetrahydrofuran; diethyl ether; Petroleum ether
T=-110°C;
参考文献
Seyferth, Dietmar; Hui, Richard C.; Wang, Wei-Liang
Journal of Organic Chemistry, 1993 , vol. 58, # 21 p. 5843 - 5845
反应条件
Irradiation.mit UV-Licht;
参考文献
Knyazev, Vadim D.; Dubinsky, Ilia A.; Slagle, Irene R.; Gutman, David
Journal of Physical Chemistry, 1994 , vol. 98, # 20 p. 5279 - 5289
反应条件
in benzene-d6
T=31.9°C; Irradiationinvestigation of homogeneous and micellar solution; Mechanism;
参考文献
Lehr, Gary F.; Turro, Nicholas J.
Tetrahedron, 1981 , vol. 37, # 19 p. 3411 - 3420
反应条件
1: (i) Et2O, (ii) /BRN= 473192/
2: aq. NaOH / dioxane
View Scheme
参考文献
Bartlett,P.D.; Tidwell,T.T.
Journal of the American Chemical Society, 1968 , vol. 90, p. 4421 - 4428
反应条件
1: methyl-isopropyl ketone With titanium tetrachloride; lithium in THF-d8 (tetrahydrofuran-d8)
T=20°C; McMurry reaction; 24 h;
2: pivalaldehyde in THF-d8 (tetrahydrofuran-d8)
Further stages.;
参考文献
Villiers, Claude; Ephritikhine, Michel
Chemistry - A European Journal, 2001 , vol. 7, # 14 p. 3043 - 3051
反应条件
2: SOCl2 / pyridine
3: (i) NaBH4, AlCl3, diglyme, (ii) NaOH, aq. H2O2, EtOH
4: H2SO4, AcOH, CrO3, H2O
5: SOCl2
6: NaNH2, liq. NH3 / diethyl ether
View Scheme
参考文献
Newman,M.S. et al.
Journal of the American Chemical Society, 1960 , vol. 82, p. 2498 - 2501
