in water T=37°C; 6 h; enzymes: leucine aminopeptidase , carboxypeptidase B; degradation in extracts of various mucosae (nasal, rectal, vaginal); female White Albino rabbits; different inhibitors (amastatin, thimerosal, thiorphan); pH=5-8; Product distributionRate constant;

in water T=37°C; 6 h; enzymes: leucine aminopeptidase , carboxypeptidase B; degradation in extracts of various mucosae (nasal, rectal, vaginal); female White Albino rabbits; different inhibitors (amastatin, thimerosal, thiorphan); pH=5-8; Product distributionRate constant;

in water T=37°C; 6 h; enzymes: leucine aminopeptidase , carboxypeptidase B; degradation in extracts of various mucosae (nasal, rectal, vaginal); female White Albino rabbits; different inhibitors (amastatin, thimerosal, thiorphan); pH=5-8; Product distributionRate constant;

hydrogen; palladium on activated charcoal in methanol 30 h;

1: 70 percent / TEA / dimethylformamide 2: 36 percent / H2 / Pd/C / methanol / 30 h View Scheme

1: 70 percent / TEA / dimethylformamide 2: 36 percent / H2 / Pd/C / methanol / 30 h View Scheme

1: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.5 h 2: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 3: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.17 h 4: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 5: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.17 h 6: 4-(aminomethyl)piperidine / CHCl3 7: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.5 h 8: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 9: 1.) 95 percent TFA / 1.) 2 h, 2.) water, G-15 Sephadex View Scheme

1: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.5 h 2: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 3: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.17 h 4: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 5: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.17 h 6: 4-(aminomethyl)piperidine / CHCl3 7: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.5 h 8: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 9: 1.) 95 percent TFA / 1.) 2 h, 2.) water, G-15 Sephadex View Scheme

1: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.17 h 2: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 3: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.17 h 4: 4-(aminomethyl)piperidine / CHCl3 5: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.5 h 6: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 7: 1.) 95 percent TFA / 1.) 2 h, 2.) water, G-15 Sephadex View Scheme

1: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.17 h 2: 4-(aminomethyl)piperidine / CHCl3 3: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl3 / 0.5 h 4: 4-(aminomethyl)piperidine / CHCl3 / 0.5 h 5: 1.) 95 percent TFA / 1.) 2 h, 2.) water, G-15 Sephadex View Scheme