3-(1,3-二氢-3-氧代-1-异苯并呋喃基)-5-氟-2,4(1H,3H)-嘧啶二酮合成路线 （共 6 条）
反应条件
sodium hydroxide; dihydrogen peroxide in methanol; dichloromethane
T=0 - 3°C; 1 h;
参考文献
Kamata; Haga; Matsui; Nagata
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3160 - 3175
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Grelan Pharmaceutical Co., Ltd.
Patent: US4528372 A1, 1985 ;
反应条件
ammonium hydroxide in pyridine; ethanol
T=60°C; 4.5 h;
参考文献
Kamata; Haga; Matsui; Nagata
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3160 - 3175
反应条件
isopropylamine in diethyl ether
0.333333 h;
参考文献
Ozaki, Shoichiro; Watanabe, Yutaka; Fujisawa, Hiroshi; Hoshiko, Tomonori
Heterocycles, 1984 , vol. 22, # 3 p. 527 - 530
反应条件
sodium hydroxide; dihydrogen peroxide in methanol; dichloromethane
T=0 - 3°C; 1 h; Yield given;
参考文献
Kamata; Haga; Matsui; Nagata
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3160 - 3175
反应条件
1: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, a) 0 deg C, 15 min, b) RT, 1 h
2: aq.HCl / ethanol / Heating
View Scheme
参考文献
Kametani, Tetsuji; Kigasawa, Kazuo; Hiiragi, Mineharu; Wakisaka, Kikuo; Nakazato, Kikuo; et al.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1219 - 1222
