反应条件
1: 1-(4-fluorophenyl)-hydrazine hydrochloride With sulfuric acid in 1,4-dioxane
T=20°C; 0.0833333 h;
2: N-methyl-4-piperidone in 1,4-dioxane
T=80°C; 2 h;
3: With potassium hydroxide in water
pH=10; Product distribution / selectivity;
参考文献
MEDIVATION TECHNOLOGIES, INC.; HUNG, David, T.; PROTTER, Andrew, Asher; JAIN, Rajendra, Parasmal; CHAKRAVARTY, Sarvajit; GIORGETTI, Marco
Patent: WO2010/51501 A1, 2010 ;
Location in patent: Page/Page column 243-244 ;
