2,3-二氟-6-硝基苯酚合成路线 （共 13 条）
反应条件
potassium hydroxide; sulfuric acid in water
参考文献
Hoechst Aktiengesellschaft
Patent: US5292967 A1, 1994 ;
反应条件
boron tribromide 1.) methanol, 17 h, 2.) CH2Cl2; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 9 p. 1362 - 1370
反应条件
1: 65 percent / K2CO3, KI / acetone / 4 h / Heating 2: 90 percent / H2, Raney Ni / ethanol 3: 1 h / 140 - 145 °C 4: PPE / 1 h / 140 - 145 °C 5: 94 percent / conc. HCl / acetic acid / 3 h / Heating View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 65 percent / K2CO3, KI / acetone / 4 h / Heating 2: 90 percent / H2, Raney Ni / ethanol 3: 1 h / 140 - 145 °C 4: PPE / 1 h / 140 - 145 °C 5: 94 percent / conc. HCl / acetic acid / 3 h / Heating 6: 62 percent / dimethylsulfoxide / 12 h / 100 - 140 °C View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
potassium carbonate; potassium iodide in acetone 4 h; Heating;
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 65 percent / K2CO3, KI / acetone / 4 h / Heating 2: 90 percent / H2, Raney Ni / ethanol View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 65 percent / K2CO3, KI / acetone / 4 h / Heating 2: 90 percent / H2, Raney Ni / ethanol 3: 1 h / 140 - 145 °C 4: PPE / 1 h / 140 - 145 °C 5: 94 percent / conc. HCl / acetic acid / 3 h / Heating 6: 53 percent / dimethylsulfoxide / 3 h / 100 - 140 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/20990 A1, 2009 ;
Location in patent: Page/Page column 126 ;
WO 2009/020990 A1
反应条件
palladium monocarbide
参考文献
SmithKline Beecham Corporation
Patent: US6262113 B1, 2001 ;
US 6262113 B1
反应条件
1.1: tetrahydrofuran / 0 - 20 °C / |Inert atmosphere 2.1: dihydrogen peroxide / acetic acid; water / 3 h / 75 °C 3.1: triethylamine; trichlorophosphate / 60 h / 105 °C 4.1: sodium dithionite / water / 1.5 h / 75 °C 5.1: triethylamine; thionyl chloride / acetonitrile / 2 h / 45 °C 5.2: 20 °C View Scheme
参考文献
Parker, Jeremy S.; Bower, John F.; Murray, Paul M.; Patel, Bharti; Talavera, Pere
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1060 - 1077
