7,8-二氟-2,3-二氢-3-甲基-4-氢恶嗪合成路线 （共 11 条）
反应条件
hydrogenchloride; ammonium hydroxide; N-chloro-succinimide; sodium borohydride; triethylamine in ethyl acetate; N,N-dimethyl-formamide
参考文献
Daiichi Seiyaku Co., Ltd.
Patent: US4880926 A1, 1989 ;
反应条件
hydrogen; nickel in ethanol
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
hydrogen; triethylamine; palladium on activated charcoal in tetrahydrofuran T=20°C; P=760 Torr; 0.5 h; Product distribution; Further Variations:Reagents;
参考文献
Journal of Heterocyclic Chemistry, , vol. 39, # 5 p. 1065 - 1069
反应条件
1: 29 percent / 10percent KOH / H2O; dimethylsulfoxide / 2 h / 18 - 20 °C 2: 65 percent / K2CO3, KI / acetone / 4 h / Heating 3: 90 percent / H2, Raney Ni / ethanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 65 percent / K2CO3, KI / acetone / 4 h / Heating 2: 90 percent / H2, Raney Ni / ethanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 1 h / 140 - 145 °C 2: PPE / 1 h / 140 - 145 °C 3: 94 percent / conc. HCl / acetic acid / 3 h / Heating View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 1 h / 140 - 145 °C 2: PPE / 1 h / 140 - 145 °C 3: 94 percent / conc. HCl / acetic acid / 3 h / Heating 4: 62 percent / dimethylsulfoxide / 12 h / 100 - 140 °C View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 1 h / 140 - 145 °C 2: PPE / 1 h / 140 - 145 °C 3: 94 percent / conc. HCl / acetic acid / 3 h / Heating 4: 53 percent / dimethylsulfoxide / 3 h / 100 - 140 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913
反应条件
bromine; triethylamine in ethyl acetate T=-78 - 0°C; 1 h;
参考文献
Satoh, Koji; Inenaga, Minako; Kanai, Kazuaki
Tetrahedron Asymmetry, 1998 , vol. 9, # 15 p. 2657 - 2662
反应条件
1: 1 h / 140 - 145 °C 2: PPE / 1 h / 140 - 145 °C 3: 94 percent / conc. HCl / acetic acid / 3 h / Heating 4: 68 percent / dimethylsulfoxide / 5 h / 100 - 140 °C View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
