6-脒基-2-萘基-4-氨基甲基苯甲酸酯二甲烷磺酸盐合成路线 （共 5 条）
反应条件
1: 83 percent / CuCN / dimethylformamide / 3 h / 160 - 170 °C
2: HCl / Ambient temperature
3: NH3 / methanol / 3 h / 50 °C
4: methanol
5: 1.) pyridine, room temp., 5 h; 2.) MeOH
View Scheme
参考文献
Aoyama; Okutome; NakayamaT.; Yaegashi; Matsui; Nunomura; Kurumi; Sakurai; Fujii
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1458 - 1471
反应条件
1: HCl / Ambient temperature
2: NH3 / methanol / 3 h / 50 °C
3: methanol
4: 1.) pyridine, room temp., 5 h; 2.) MeOH
View Scheme
参考文献
Aoyama; Okutome; NakayamaT.; Yaegashi; Matsui; Nunomura; Kurumi; Sakurai; Fujii
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1458 - 1471
反应条件
1: NH3 / methanol / 3 h / 50 °C
2: methanol
3: 1.) pyridine, room temp., 5 h; 2.) MeOH
View Scheme
参考文献
Aoyama; Okutome; NakayamaT.; Yaegashi; Matsui; Nunomura; Kurumi; Sakurai; Fujii
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1458 - 1471
反应条件
1: methanol
2: 1.) pyridine, room temp., 5 h; 2.) MeOH
View Scheme
参考文献
Aoyama; Okutome; NakayamaT.; Yaegashi; Matsui; Nunomura; Kurumi; Sakurai; Fujii
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1458 - 1471
反应条件
1.) pyridine, room temp., 5 h; 2.) MeOH; Yield given. Multistep reaction;
参考文献
Aoyama; Okutome; NakayamaT.; Yaegashi; Matsui; Nunomura; Kurumi; Sakurai; Fujii
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1458 - 1471
