4-[2-(1-哌啶基)乙基]苯酚合成路线 （共 8 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
T=60°C; 18 h;
参考文献
Barchuk, William T.; Dunford, Paul J.; Edwards, James P.; Fourie, Anne M.; Karlsson, Lars; Quan, Joanne M.
Patent: US2008/194630 A1, 2008 ;
Location in patent: Page/Page column 36 ;
US 20080194630 A1
反应条件
1: aqueous HI / 135 °C
View Scheme
参考文献
Cheng et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 4081,4082
反应条件
hydrogenchloride
T=170°C;
参考文献
Kindler et al.
Archiv der Pharmazie (Weinheim, Germany), 1950 , vol. 283, p. 184,187
反应条件
triethylamine in acetonitrile
7 h; Heating;
参考文献
Shen, Yanhong; Sheng, Rong; Zhang, Jing; He, Qiaojun; Yang, Bo; Hu, Yongzhou
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 16 p. 7646 - 7653
参考文献
Cheng et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 4081,4082
反应条件
1: palladium/barium sulfate; methanol / Hydrogenation
2: concentrated aqueous hydrochloric acid / 170 °C
View Scheme
参考文献
Kindler et al.
Archiv der Pharmazie (Weinheim, Germany), 1950 , vol. 283, p. 184,187
反应条件
1: palladium/barium sulfate / Hydrogenation
2: aqueous sulfuric acid; potassium nitrite / Erwaermen der mit Schwefelsaeure angereichten Reaktionsgemisches.
View Scheme
参考文献
Kindler et al.
Archiv der Pharmazie (Weinheim, Germany), 1950 , vol. 283, p. 184,187
反应条件
1: palladium/barium sulfate; methanol / Hydrogenation
2: concentrated aqueous hydrochloric acid / 170 °C
View Scheme
参考文献
Kindler et al.
Archiv der Pharmazie (Weinheim, Germany), 1950 , vol. 283, p. 184,187
