反应条件
1.1: 65 percent / aq. HCl; NaNO2; NaI / 3 h / 0 °C 2.1: NaH / tetrahydrofuran / 0.25 h 2.2: 98 percent / tetrahydrofuran / 16 h 3.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 3.2: 79 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 4.1: 93 percent / BBr3 / CH2Cl2 / 16 h / 20 °C 5.1: 66 percent / CH2Cl2; diethyl ether View Scheme
参考文献
O'Meara, Jeff A.; Yoakim, Christiane; Bonneau, Pierre R.; Boes, Michael; Cordingley, Michael G.; Deziel, Robert; Doyon, Louise; Duan, Jianmin; Garneau, Michel; Guse, Ingrid; Landry, Serge; Malenfant, Eric; Naud, Julie; Ogilvie, William W.; Thavonekham, Bounkham; Simoneau, Bruno
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5580 - 5588
