3,4-二甲氧基-5-羟基苯甲酸甲酯合成路线 （共 26 条）
反应条件
sulfuric acid T=20°C; 24 h;
参考文献
Ghinet, Alina; Rigo, Benoit; Henichart, Jean-Pierre; Le Broc-Ryckewaert, Delphine; Pommery, Jean; Pommery, Nicole; Thuru, Xavier; Quesnel, Bruno; Gautret, Philippe
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 20 p. 6042 - 6054
反应条件
hydrogen; palladium on activated charcoal in methanol 20 h;
参考文献
Tanaka, Masahide; Ikeya, Yukinobu; Mitsuhashi, Hiroshi; Maruno, Masao; Wakamatsu, Takeshi
Tetrahedron, 1995 , vol. 51, # 43 p. 11703 - 11724
反应条件
sodium hydroxide; sulfuric acid; sodium carbonate; dimethyl sulfate in methanol; water
参考文献
Tsumura and Co.
Patent: US5321135 A1, 1994 ;
反应条件
sodium hydroxide; sulfuric acid; sodium carbonate; dimethyl sulfate in methanol; water
参考文献
TSUMURA and CO.
Patent: EP594890 A1, 1994 ;
反应条件
tributylphosphine; 1,3-bis-(diphenylphosphino)propane; N-ethyl-N,N-diisopropylamine; palladium diacetate in N,N-dimethyl-formamide T=130°C; 3 h;
参考文献
Tetrahedron, , vol. 63, # 2 p. 396 - 408
反应条件
hydrogenchloride in methanol
反应条件
1: 3,4,5-trihydroxybenzoic acid methyl ester With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.5 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 2 h; Inert atmosphere;
参考文献
Kwak, Jae-Hwan; Lee, Seul; Park, Eun-Seok; In, Jin-Kyung; Song, Jiho; Kim, Young Jin; Choi, Nam Song; Lee, Heesoon; Yun, Yeo-Pyo; Hong, Jin Tae; Kwak, Young-Shin; Min, Kyung Hoon; Jung, Jae-Kyung
Archives of Pharmacal Research, 2011 , vol. 34, # 7 p. 1107 - 1112
反应条件
lithium carbonate in N,N-dimethyl-formamide T=50 - 55°C; 18 h;
参考文献
Tetrahedron, , vol. 61, # 7 p. 1909 - 1918
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50 - 55°C;
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
2: 97 percent / K2CO3 / acetone / 1.5 h / Heating 3: 100 percent / hydrogen / 10percent Pd-C / methanol / 20 h View Scheme
参考文献
Tetrahedron, , vol. 51, # 43 p. 11703 - 11724
