4-氯-5-碘-6-甲基嘧啶合成路线 （共 6 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine T=80°C; 12 h;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Watanabe, Ryo; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2719 - 2724
反应条件
sodium carbonate; toluene-4-sulfonic acid hydrazide 1.) CHCl3, reflux, 12 h, 2.) reflux, 30 min;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1984 , # 3 p. 252 - 254
反应条件
ammonia in ethanol T=120°C; 12 h;
参考文献
Sakamoto; Kondo; Yamanaka
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2410 - 2416
反应条件
trichlorophosphate
T=90°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28958 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
1: water / Raney-Nickel / Reflux
2: acetic acid; N-iodo-succinimide / 30.25 h / 20 °C
3: trichlorophosphate / 1 h / 90 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28958 A1, 2012 ;
反应条件
1: iodine cloride; acetic acid / 60 °C
2: trichlorophosphate / toluene / 20 °C
View Scheme
参考文献
Suzuki, Naoyuki; Shiota, Takeshi; Watanabe, Fumihiko; Haga, Norihiro; Murashi, Takami; Ohara, Takafumi; Matsuo, Kenji; Oomori, Naoki; Yari, Hiroshi; Dohi, Keiji; Inoue, Makiko; Iguchi, Motofumi; Sentou, Jyunko; Wada, Tooru
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1601 - 1606
