3-(5-硝基-2-噻吩)吡啶合成路线 （共 2 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether
T=90°C; Suzuki coupling; 1 h;
参考文献
Denton, Travis T.; Zhang, Xiaodong; Cashman, John R.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 224 - 239
反应条件
1.1: n-BuLi / toluene; hexane; tetrahydrofuran / -50 °C
1.2: triisopropyl borate / toluene; tetrahydrofuran; hexane / -50 - -15 °C
1.3: 73 percent / aq. NaOH / toluene; tetrahydrofuran; hexane
2.1: 91 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 1 h / 90 °C
View Scheme
参考文献
Denton, Travis T.; Zhang, Xiaodong; Cashman, John R.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 224 - 239
