2-氨基-4,5,6,7-四氢-苯并[b]噻吩-3-羧酸 (4-甲氧基-苯基)酰胺合成路线 （共 4 条）
反应条件
morpholine; sulfur in N,N-dimethyl-formamide T=50°C; 6 h;
参考文献
Astellas Pharma Inc.; HACHIYA, Shunichiro; MIURA, Masanori; IMAMURA, Yoshimasa; KAGA, Daisuke; SATO, Ippei; MORITOMO, Hiroyuki; KATO, Koji; TERAI, Kazuhiro; TERADA, Yoh
Patent: EP2565190 A1, 2013 ;
Location in patent: Paragraph 0129 ;
反应条件
diethylamine in ethanol T=50°C; 3 h;
参考文献
Schellhase; Bohm; Pech
Pharmazie, 1984 , vol. 39, # 1 p. 19 - 21
反应条件
1: 33 percent / CH3COONH4, CH3COOH / benzene / 6 h / Heating 2: 65 percent / S, Et2NH / ethanol / 3 h / 50 °C View Scheme
参考文献
Pharmazie, , vol. 39, # 1 p. 19 - 21
反应条件
1: 42 percent / 4 h / 170 °C 2: 33 percent / CH3COONH4, CH3COOH / benzene / 6 h / Heating 3: 65 percent / S, Et2NH / ethanol / 3 h / 50 °C View Scheme
参考文献
Pharmazie, , vol. 39, # 1 p. 19 - 21
