2-正丁基-4-氯-5-甲酰基咪唑合成路线 （共 45 条）
反应条件
sodium tetrahydroborate; potassium carbonate 1.) dimethylacetamide, -10 deg C, 2 h; room temp., 2 h, 2.) MeOH, room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Larsen; King; Chen; Corley; Foster; Roberts; Yang; Lieberman; Reamer; Tschaen; Verhoeven; Reider; Lo; Rossano; Brookes; Meloni; Moore; Arnett
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6391 - 6394
反应条件
sodium hydroxide; tetrabutylammomium bromide in n-butyl chloride; water T=25 - 50°C; 32 h;
参考文献
WO2006/38223 A1, ;
Page/Page column 6-7 ;
反应条件
1: With potassium carbonate in 1-methyl-pyrrolidin-2-one
T=70 - 75°C;
2: With sodium tetrahydroborate in 1-methyl-pyrrolidin-2-one
T=30°C;
3: With water in 1-methyl-pyrrolidin-2-one; isopropyl alcohol
T=75 - 80°C; 1.5 h;
参考文献
ALEMBIC LIMITED; DEO, Keshav; DESAI, Sanjay; RATHOD, Dhiraj; PARIKH, Chirag; MOKAL, Ramesh
Patent: WO2010/29457 A2, 2010 ;
Location in patent: Page/Page column 11-12 ;
反应条件
1.1: 90 percent / NaBH4 / methanol / 2 h / 20 °C
2.1: NaOMe / dimethylformamide / 0.5 h / 25 °C
2.2: 40 percent / dimethylformamide / 24 h / 20 °C
View Scheme
参考文献
Ambalavanan; Palani; Ponnuswamy; Thirumuruhan; Yathirajan; Prabhuswamy; Raju; Nagaraja; Mohana
Molecular Crystals and Liquid Crystals, 2003 , vol. 393, p. 75 - 82
反应条件
sodium hydroxide; tetrabutylammomium bromide in toluene
T=20°C; 2 h;
参考文献
Sonegawa, Motoharu; Yokota, Masayuki; Tomiyama, Hiroshi; Tomiyama, Tsuyoshi
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 5 p. 706 - 710
