6-氟-2,3-喹喔啉二甲醇二乙酸酯 1,4-二氧化物合成路线 （共 4 条）
反应条件
triethylamine in acetone
0.5 h; Heating;
参考文献
Musatova, I. S.; Elina, A. S.; Padeiskaya, E. N.; Shipilova, L. D.; Yakobson, G. G.; Furin, G. G.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 598 - 601
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 934 - 938
反应条件
1: 99 percent / Br2 / CH2Cl2; dimethylformamide / 3 h / 58 °C
2: 54.7 percent / Et3N / acetone / 0.5 h / Heating
View Scheme
参考文献
Musatova, I. S.; Elina, A. S.; Padeiskaya, E. N.; Shipilova, L. D.; Yakobson, G. G.; Furin, G. G.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 598 - 601
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 934 - 938
反应条件
1: 94.6 percent / butyl amine / 20 h / 20 - 25 °C
2: 99 percent / Br2 / CH2Cl2; dimethylformamide / 3 h / 58 °C
3: 54.7 percent / Et3N / acetone / 0.5 h / Heating
View Scheme
参考文献
Musatova, I. S.; Elina, A. S.; Padeiskaya, E. N.; Shipilova, L. D.; Yakobson, G. G.; Furin, G. G.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 598 - 601
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 934 - 938
反应条件
sodium hydroxide in methanol
T=20 - 22°C; 0.75 h;
参考文献
Musatova, I. S.; Elina, A. S.; Padeiskaya, E. N.; Shipilova, L. D.; Yakobson, G. G.; Furin, G. G.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 598 - 601
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 934 - 938
