2-氟-DL-α-苯基甘氨酸合成路线 （共 7 条）
反应条件
sodium hydroxide; hydrazine hydrate; palladium on activated charcoal in water Hydrogenolysis; 10 h; Heating;
参考文献
Davies, Antony J.; Ashwood, Michael S.; Cottrell, Ian F.
Synthetic Communications, 2000 , vol. 30, # 6 p. 1095 - 1102
反应条件
1: Na2S2O5 / methanol; H2O / 2 h / 35 °C 2: 85 percent / aq. H2O2; K2CO3 / dimethylsulfoxide / 16.5 h / 21 - 35 °C 3: 86 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 4: 78 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 85 percent / aq. H2O2; K2CO3 / dimethylsulfoxide / 16.5 h / 21 - 35 °C 2: 86 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 3: 78 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 86 percent / NaOH; H2O / various solvent(s) / 3.5 h / Heating 2: 78 percent / hydrazine hydrate; NaOH / Pd/C / H2O; various solvent(s) / 10 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 30, # 6 p. 1095 - 1102
反应条件
1: 74 percent / NaHCO3 / H2O; acetone / 3 h / -5 - 20 °C 2: 86 percent / H2O / aminoacylase from Streptoverticillium olivoreticuli View Scheme
参考文献
Russian Journal of Bioorganic Chemistry, , vol. 19, # 4 p. 228 - 232
Bioorganicheskaya Khimiya, , vol. 19, # 4 p. 467 - 473
反应条件
sodium carbonate in 1,4-dioxane; water
T=20°C;
参考文献
Le Roy, Isabelle; Mouysset, Dominique; Mignani, Serge; Vuilhorgne, Marc; Stella, Lucien
Tetrahedron, 2003 , vol. 59, # 21 p. 3719 - 3727
反应条件
1: With thionyl chloride
18 h; Heating;
2: With triethylamine in dichloromethane
T=20°C; 0.166667 h;
参考文献
Le Roy, Isabelle; Mouysset, Dominique; Mignani, Serge; Vuilhorgne, Marc; Stella, Lucien
Tetrahedron, 2003 , vol. 59, # 21 p. 3719 - 3727
