6-氟-3-哌啶-4-基-1,2-苯并异唑盐酸盐合成路线 （共 28 条）
反应条件
tetra-(n-butyl)ammonium iodide; diisopropylamine in methanol T=45°C; 48 h;
参考文献
Xu, Weichu; Wright, George E.; Yanachkova, Milka; Yanachkov, Ivan B.
Letters in Organic Chemistry, 2014 , vol. 11, # 6 p. 470 - 473
反应条件
sodium carbonate in methanol; 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; dichloromethane; water
参考文献
MSN LABORATORIES LIMITED
Patent: US2011/293889 A1, 2011 ;
反应条件
sodium hydroxide; potassium iodide; sodium carbonate; acetic acid in water; acetonitrile
参考文献
MSN LABORATORIES LIMITED
Patent: US2011/293889 A1, 2011 ;
反应条件
1: sodium hydroxide / water 2: sodium borohydride / dichloromethane; methanol View Scheme
参考文献
MSN LABORATORIES LIMITED
Patent: US2011/293889 A1, 2011 ;
反应条件
potassium carbonate in acetone 6 h; Heating / reflux;
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2006/46082 A1, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
sodium carbonate in methanol T=73 - 75°C; 4 - 4.5 h; Product distribution / selectivity;
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2006/5974 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
反应条件
sodium carbonate in water T=110 - 120°C; 0.666667 h; Product distribution / selectivity;
参考文献
Zhang, Guiling; Zhu, Yidong; Fan, Chuanwen; Zhang, Minghui; Wang, Jingyi
Patent: US2010/130740 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
1: 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole monohydrochloride With potassium carbonate in acetonitrile T=25 - 60°C; 1.16667 h; 2: 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one palmitate ester With tetrabutylammomium bromide; potassium iodide T=20 - 75°C; 14 h;
参考文献
WO2012/164582 A1, ;
Page/Page column 11-12 ;
