1: 97 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 2 h 2: BF3*Et2O; t-butyl nitrite / CH2Cl2 / -15 - 5 °C 3: 160 mg / 0.67 h / 130 °C View Scheme

1: 7-nitro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione With potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere; 2: With diethyl chlorophosphate in tetrahydrofuran; N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere; 3: isocyano-acetic acid ethyl ester With potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C; 2.5 h; Inert atmosphere;

sulfuric acid; nitric acid in ethyl acetate

1: C15H14BrN3O6 With N-bromosuccinmide; dibenzoyl peroxide in benzene T=20°C; 22 h; Irradiation; 2: methylamine With N-ethyl-N,N-diisopropylamine in methanol 3 h; Reflux;

in N-methyl-acetamide; water; acetic acid

1: sodium hydride; diethyl chlorophosphate / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C 2: 1.79 g / sodium hydride / dimethylformamide; tetrahydrofuran / 18 h View Scheme

1.1: dimethyl sulfoxide / 2.5 h / 140 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 0.5 h / 0 °C / Inert atmosphere 2.3: 2.5 h / 0 - 20 °C / Inert atmosphere View Scheme

sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide 18 h;